{"id":5161,"date":"2015-12-08T20:03:32","date_gmt":"2015-12-08T20:03:32","guid":{"rendered":"http:\/\/www.marijuana.com\/?p=45650"},"modified":"2015-12-08T20:03:32","modified_gmt":"2015-12-08T20:03:32","slug":"largest-study-to-date-finds-cbd-cannabinoid-helpful-for-children-with-epilepsy","status":"publish","type":"post","link":"https:\/\/cannitrol.com\/blog\/largest-study-to-date-finds-cbd-cannabinoid-helpful-for-children-with-epilepsy\/","title":{"rendered":"Largest Study to Date Finds CBD Cannabinoid Helpful For Children with Epilepsy"},"content":{"rendered":"<div id=\"wp_fb_like_button\" style=\"margin:5px 0 5px 5px;float:right;height:100px;\"><script src=\"http:\/\/connect.facebook.net\/en_US\/all.js#xfbml=1\"><\/script><fb:like href=\"https:\/\/cannitrol.com\/blog\/largest-study-to-date-finds-cbd-cannabinoid-helpful-for-children-with-epilepsy\/\" send=\"true\" layout=\"standard\" width=\"450\" show_faces=\"false\" font=\"arial\" action=\"like\" colorscheme=\"light\"><\/fb:like><\/div><p>Providing some much-needed hope for parents of kids suffering from severe forms of epilepsy, a <a href=\"https:\/\/www.aesnet.org\/meetings_events\/annual_meeting_abstracts\/view\/2414222\" target=\"_blank\">new study<\/a> provides further evidence that marijuana\u2019s non-psychoactive cannabinoid, Cannabidiol (a.k.a. CBD), offers a safe and effective form of anti-epileptic therapy.<\/p>\n<p>As parents and guardians of epileptic children have been scrambling to obtain those few strains known to be high in the miracle cannabinoid \u2013 like <a href=\"http:\/\/www.marijuana.com\/blog\/news\/2013\/06\/charlottes-web-of-suffering-six-year-old-colorado-girl-with-dravet-syndrome-finds-relief-from-marijuana-high-in-cbd\/\" target=\"_blank\">Charlotte&#8217;s Web<\/a> and <a href=\"http:\/\/www.marijuana.com\/blog\/news\/2015\/04\/georgia-legalized-medical-marijuana-oils-yesterday\/\" target=\"_blank\">Haleigh&#8217;s Hope<\/a> \u2013 some were acting out of blind faith rather than scientific evidence. Until recently, there had been scarce scientific data on cannabidiol&#8217;s overall safety and efficacy as an anti-epileptic. Fortunately for all, that nagging little question has been put to bed this week \u2013 at least for some.<\/p>\n<p>Praised as being the largest study performed to date, the American Epilepsy Society met in Philadelphia this week to review the results from the 2014 study:<\/p>\n<blockquote>\n<p>\u201c261 patients received at least 3 months of treatment and had available data at last group data collection (136 (52%) were male; average age 11.8 years, range 4 months-41 years; average weight 38 kg; range 6.4-127). The most common diagnoses were DS (44; 17%) and LGS (40; 15%). The average # of concomitant AEDs was 3.0. After 3 months of therapy, the median overall seizure frequency reductioHimn was 45.1% in all patients and 62.7% in DS patients. For LGS patients, the median reduction of atonic seizures from baseline was 71.1%. Among all patients, 47% had a ?50% reduction in seizures. Seizure-freedom at 3 months occurred in 9% of patients and 13% of DS patients. Clobazam co-therapy was associated with a higher rate of treatment response (?50% convulsive seizure reduction): 57% v. 39%; this may reflect elevations in the desmethyl clobazam metabolite. Safety data from 313 patients representing 180 patient years was available at 16 sites. Adverse events in ?10% of patients included somnolence (23%), diarrhea (23%), fatigue (17%), decreased appetite (17%), convulsions (17%) and vomiting (10%). 14 patients (4%) had an adverse event leading to discontinuation of CBD. 36 patients (12%) withdrew primarily due to lack of efficacy.&#8221;<\/p>\n<\/blockquote>\n<p>While the CBD cannabinoid\u00a0was shown to be beneficial for most participants, unfortunately for some, epilepsy can be one of the more difficult conditions to control. Approximately 1\/3 of all patients have an intractable form of epilepsy.<\/p>\n<p style=\"margin: 12px auto 6px;font-family: Helvetica, Arial, sans-serif;font-style: normal;font-variant: normal;font-weight: normal;font-size: 14px;line-height: normal;text-align: center\"><a style=\"text-decoration: underline\" title=\"View American Epilepsy Society | Working Toward a World without Epilepsy on Scribd\" href=\"https:\/\/www.scribd.com\/doc\/292645181\/American-Epilepsy-Society-Working-Toward-a-World-without-Epilepsy\">American Epilepsy Society | Working Toward a World without Epilepsy<\/a><\/p>\n<p><span class='embed-youtube' style='text-align:center; display: block;'><iframe class='youtube-player' type='text\/html' width='702' height='425' src='http:\/\/www.youtube.com\/embed\/m97rIMKUsLc?version=3&#038;rel=1&#038;fs=1&#038;autohide=2&#038;showsearch=0&#038;showinfo=1&#038;iv_load_policy=1&#038;wmode=transparent' frameborder='0' allowfullscreen='true'><\/iframe><\/span> <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Providing some much-needed hope for parents of kids suffering from severe forms of epilepsy, a new study provides further evidence that marijuana\u2019s non-psychoactive cannabinoid, Cannabidiol (a.k.a. CBD), offers a safe and effective form of anti-epileptic therapy. As parents and guardians of epileptic children have been scrambling to obtain those few strains known to be high [&#8230;] <\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[968,330,534,2421,9,1777,1778,1,3],"tags":[3539,2908,3108,2427,4345,4346],"_links":{"self":[{"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/posts\/5161"}],"collection":[{"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/comments?post=5161"}],"version-history":[{"count":0,"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/posts\/5161\/revisions"}],"wp:attachment":[{"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/media?parent=5161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/categories?post=5161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cannitrol.com\/blog\/wp-json\/wp\/v2\/tags?post=5161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}